Brian Delaney presents "Dietary Restriction Methods" and Bill Faloon with an Age Reversal Update

Brian Manning Delaney presents "Navigating the Labyrinth of Dietary Restriction Methods." William Faloon presents an Age Reversal Update

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Presentations:

Brian Delaney ~ 2019-02-28, Delaney dietary restriction .pptx

Bill Faloon ~ Bill Faloon church 2-28- 2019.pptx

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Basic Info:

Brian Manning Delaney presents "Navigating the Labyrinth of Dietary Restriction Methods." William Faloon presents an Age Reversal Update Church of Perpetual Life, a science-based church is open to people of all faiths & belief systems. We are non-denominational & non-judgmental and a central gathering place of Transhumans. What unites us is our common faith, belief, and desire in Unlimited Life Spans.

Transcription:

Here at Perpetual life we teach we're teaching and learning about new technologies that we can use to stay healthy and live unlimited lives embracing the philosophies of nikolai fedorov and the philosophy and ideas of Asura through C Clarke our ultimate desire is to find ways to extend healthy human living indefinitely and I hope that you will take away some great ideas this evening if you are new here to the church either in person or online I'd like to encourage you to watch our recordings we have our past events recorded on their YouTube channel and you can access that through our website in the upper left corner of our website we have the convey a link that will go to our YouTube channel and if you're away from the church you can also join our livestream from the link right next to the youtube link I'd also like you to share this information this life-saving information with your friends and family people that you love and show that show them how much you care about them by showing them what's going on here and the technology that's being developed and discovered in a healthy unlimited lifespans next month we have our service on March 28th and you can join us with Gabriel Rothblatt who will be giving us some information on the terrace a movement and age reversal we also have Amanda Patel coming he spoke at the red fest last year the red fest red is our aad revolution against aging and death and it's the largest conference of its kind of people looking for unlimited lifespans people who are looking to reverse the aging process and they are meeting in in Nevada this year a thousand people from all over the world converge and it Sam it's an amazing event well Anand Patel spoke and part of his book will be on a regeneration he spoke about regenerating teeth an amazing thing he's doing so he'll be here as well as Gabriel Rothblatt next month as usual we'll be starting at 7 o'clock with the doors opening at 6:00 and next month March I'd like to encourage you to bring a friend it's bring a friend month so tell your loved ones your family your friends the people that you want to live a healthy long life and bring them if you can or invite them to watch our livestream next month is special for that who's here with us for the very first time tonight very first time here at Perpetual life two three four five six seven eight nine ten eleven twelve Wow how did you hear about this event this place from your friend your friends how many people received a text message for the event tonight and how about a phone call maybe you received a an email so if you'd like to receive your emails we I'm very very glad you're getting those and I will those of you who are Newell I'll send you emails to invite you in the future and if at any time you change your email or want to be taken off just let us know and we'll make that happen for you is very easy to do I would also like to invite you to visit our longevity library which is just outside these doors and check out a book bring it back next month we also have perpetual life t-shirts and they'll be available downstairs now in March March 18th is a Monday Deborah who you met at the check-in table she's doing a special meditation class March 18th here at Perpetual life and that will be at 7 o'clock to 8:15 so you're welcome to go there if you're interested in that ask her about it or myself and we'll get you some more information about that class being taught here on meditation the idea is is stress a positive motivational tool that's their topic I'd like to mention also that would be very grateful to accept any donations that you'd like to give us we have a donation box downstairs at the check-in table and on the beverage table and your donations help us to support and continue the work that we are doing here bringing great speakers and excellent presentations on age reversal and your donations do make a big difference and we thank you for that I recently met with a member who want to discuss adding the church to their will while it's our my honor to discuss this with you I'm also available to come and speak with you and talk with you about cryonics and other opportunities for extreme longevity so feel free to give me a call or reach out to me with an email and I'm happy to talk with you about that personally all right so we're going to get right into our program this evening and our first speaker this evening helped to found the calorie restriction Society international and has been its president for over 20 years he has published a book on dietary restrictions with ELISA Wolford the longevity diet as well as numerous articles on life extension he is president of the age reversal that work that was formerly the Society of the rescue of our elders a group helping to advance research into the very near term solution on the problem of Aging has appeared on numerous television channels around the world including CNN BBC CBS ABC and has appeared on People magazine he is also an advisory team member for the Coalition for radical life extension and he has a read fest global ambassador so please help me welcome to the stage Brian Delaney to give his presentation navigating the labyrinth of dietary restriction methods Brian Delaney [Applause] oh yeah one of these ready thanks everyone for coming it's always great actually for me to be able to give these talks because it forces me to think through complicated science that I often don't do on my own but when you have to present it to someone you're motivated to actually try to get the big picture I'm gonna start with a little bit of a personal story on my background if this is gonna work do I have to point it somewhere else or did their perhaps there we go whoops Runcie Arfa so long my muscles of ways to go a I can't even push the pointer now I am pushing this with gusto it is not working oh wait it's working okay this is this is a clicker and a laser okay well I may need that what's a great laser Wow so my point this at some innocuous place this is my typical daily diet as an adult until I was about to turn 29 this is not an exaggeration this is how I ate and my parents might be watching the live stream it's not your fault um they fed me really well I did when I was before I went to went away to school at 16 I hate at home very well but even then I was kind of a sugar addict I would go to the local store and take my my allowance and purchase a box this is at least once a week of confectioner's sugar and sort of drink the confectioners sugar that's how much of a sugar addict I was I don't know how I'm alive it's amazing but then I realized okay maybe too much sugar isn't so good it was so good so I started I switched to cheeseburgers and and fries and then in April of 1992 I got what I now know I the diagnosis wasn't clear at the time but was Crohn's disease some you know what that is it's an inflammatory bowel disease and it was an extreme and extremely rapid onset of this inflammation of the digital small intestine it's sort of like closed and you know it started leaking and I had a fever and I was in the hospital and you know it gave me a bunch of prednisone and I got I got better pretty quickly but and by the way like a lot of us back then anyway I thought with enough exercise I could eat that way and would have no consequences and obviously I was wrong I was thin because I did exercise enough to kind of with you're creative enough virtue to undo the vice of the diet to some degree but not enough to avoid Crohn's disease and what the doctors told me all right this is I think I needed another one Neal hope there we go um the advice that they gave me was I have to eat a low residue diet which basically means more or less low fiber they told me white bread rice meat ice cream these would be fine and I would have to take sulfasalazine these little horrible things that I stupidly took for years even though I didn't need to and then periodically prednisone all right this this this actually is non-functional if there's okay okay thanks and then occasionally occasionally prednisone if had a serious flare-up and I was told that I would have to have portions of my intestines removed probably every ten years and had a very high chance of dying of cancer by the time I was 50 so I said I don't like that so I went to the medical library and started reading about diet and that's when I learned about calorie restriction and I was you know RB to gray who's almost the exact same age as me tells the same story that he assumed everyone was working on life extension because you know what why wouldn't want it's the most obvious goal and it was only later later that they discovered that wasn't true reading the literature that's when I realized it wasn't true that everyone was working on life extension noise there's a few people working on it and this crazy guy Roy Walford doing research into calorie restriction so I called him up and we talked and eventually it took a couple years but we started with some other people the Sierra Society and I did not eat that diet at all and I got off selfs Alassane and I actually I've been scoped numerous times recently and the results are pristine so I completely cured the Crohn's disease with my diet which is sort of amazing so a few quick preliminaries I'm gonna have to speak more quickly here because I think there's so much to get through you know a lot of people have seen the debates about whether or not it works and there are some downsides that are worth mentioning arguments for and by the way we're calling it dietary restriction now it's not clear that it's the calories it could be the protein or some other component hundreds of studies and had been mostly mice showing that it extends lifespan and humans we had the effects of low food availability after World War Two in Europe these people lived a lot longer and it wasn't even that high quality food some fasting studies showing improved health Okinawa is a kind of natural see our experiments where people tend to live much longer and then we have these more careful modern studies Luigi Fontana's examination of our society members sometimes hypersensitive and sometimes all right it too hard back stop Thanks and then the calorie results that's a very carefully done study that showed that 25% restriction and energy has a whole bunch of improvements in biomarkers right forward the arguments against it are first there's this argument that in wilde derived or wild-type mice it doesn't work and that's based on a like one or two studies that really didn't show that it didn't work because the wild drive mice naturally eat very little and the way that you actually come up with a percentage CR for the experimental group is based on what the control group is eating and because the control group is eating so little because that's how little wild drive mice eat these see art animals are eating too little so they were starving to death and you can see that in the mortality curves there's a whole bunch of early deaths but the ones that live the longest live longer than the control group the second argument is basically I think the incorrect because the non-si our maximum human lifespan is not 120 it's probably about 105 I think anyone living past 105 probably has been on unintentional CR for various years during their lives now this next one irritates me next slide great there are correlations between having a low body mass index and dying earlier these are merely correlations some people have seen these u-shaped curves that plot out body mass index with mortality if you have a really high BMI or really low one you tend to have higher mortality but it turns out when you control for things that can make people thin it becomes a j-shaped curve and when you control for more and more it becomes almost a straight line but the fact is you can't control for anything because there's so many of the things that can make people thin go undiagnosed especially inflammatory bowel disease and celiac disease so the BMI evidence is unusually weak and I wanted to see a little bit more about that great a kind of pedantic summary of the problem no no it's just moving on its own back I'm sorry forward yeah Ford I'm just not gonna touch this anymore okay great there's a logical problem or error known as affirming the antecedents if it's raining I will take my umbrella I took my umbrella therefore it was raining that's obviously not logically correct if people go on CR they become thin therefore thin people are on CR not valid forward but to put it kind of more to separate out the two problems that the basic problem is you can control for diseases that make people thin as I noted but there's even separate problem that makes the BMI mortality correlation difficult to apply to whether or not see our works in humans thin people even if they don't have these undiagnosed or diagnosed diseases often aren't upon any kind of dietary restriction partly because it's certainly not a healthy dietary restriction because there are a lot of people who are thin and eating less and they're just eating really bad food but the other thing is there's so many societal pressures to be thin that the people who are naturally thin are probably not on CR it could even be the people who have BMI of 23 or 24 are on CR because they have the pressure not to be fat and this is actually horrible because I hear people all the time tell me oh I read in you know Newsweek that it's bad to have my BMI of 18 or 17 someone who is perfectly healthy and eating vegetables and getting all their nutrients and this would they start eating more and they're basically going off CR that they had unintentionally been on and shortening their lifespan it's just unbelievable it's and it's just a sort of logical error okay next and again next Roy Walford took this B's mortality curves scene in mice and just translated the percentages to humans next and that was a mistake almost certainly we know now from studies of non-human primates that probably apply to humans we can't be certain that the percentage gains seen in mice can't simply be applied to humans it's it could even be an absolute number of months for years so next day there we go good sorry back I actually was able to fool myself I think the conclusion is that normal dietary restriction it's now called continual or continuous it's not literally continuous but almost certainly will slow aging at least a bit and it will greatly reduce risks of many ages associated diseases so if you have a high familial risk for cancer or Alzheimer's or heart disease you want to consider more than most people would going on CR it works better if I'm pointing this way now the downsides to this continuous or continual severe dietary restriction are these the ones people talk about feeling coldest never seems like a serious problem to me as we say in Swedish there's no such thing as bad weather only bad clothing it rhymes in Swedish and so now that doesn't apply to places that are further south of Sweden because if it's too hot you can't take off clothing yeah but isn't that sensing the problem the bone loss issue people do get thinner bones but bone is a tissue that's constantly remodeling itself if you're lighter you don't need as thick skeletal structures that's it's not clear that's a problem cessation of menses that could be a problem used running a pregnant of course the low fee testosterone is something that men in the crs society constantly complained about because some of them actually had actually total testosterone went down as well and they had that testosterone of a you know three-year-old girl and I I don't mind never got quite that low but it was it was low at points and I didn't even realize it until I went off CR which I had to do when I had surgery years ago excited to recover but before then when I was living in Stockholm might be doing these translations or kind of preparing a text to teach with these male colleagues at cafes and these women would walk by and they'd be rubbernecking and I'm kind of looking at Plato thinking how can these people be more important than Plato I just I didn't get it and then I went off CR and then suddenly I got it it was sort of amazing how the absence of testosterone sort of didn't wasn't noticeable to me until it came back and then it's sort of like being uncashed rated right that's what I was missing this is kind of feeling of vigor and The Hunger is a problem for some people it can be extreme if you're on extreme CR certain species of mice need to be caged individually because they will actually cannibalize each other that's how hungry they are social challenges I think that's downplayed by a lot of people on CR but it can be it can be real you kind of used to weighing out the perfect dinner and someone invites you to eat and you have to explain to them you can't eat certain foods you just often to stay at home a lot of people have done that I did that sometimes risk of eating disorders and then simply looking too scrawny sometimes if you start out then as I did now the point of many people switching to other types of dietary restriction is so-called non-continuous like you know time restricted windows within a day or every other day fasting or revolt along goes fasting then we can diet is that it could be that some of these downsides are more manageable it's not that they would be that the overall quantity of them would go down that's not clear but they're compressed into a short period so you can be a functional unit for a week when you're on of you know week-long diet and then get back to normal for example and just very quick thing when people consider CR they think I hate they have to do it in some radical form it doesn't have to be extreme the ROI Walford used to say if you don't want to do an extreme dietary change just eat more vegetables and leave the table before you're full and the Okinawa would say eat until you're 80% full that's actually a Confucian saying I want to just note something very important here before we go on the big picture and Bill is gonna be talking about most of these things here after me something that we always in the crs society especially starting when the resveratrol research was was getting a lot of press something that we always thought about is when is the post dietary restriction era going to dawn because there are some foodies in our group where they're just gonna keep eating broccoli no matter what kind of magical nostrums science comes up with but I'm not like that I would have to go back to my previous well maybe not Wendy's but I would have to eat differently from I do now from the way I do now if there are really effective age of our soul treatments and they are on the way all kinds of amazing things and so when thinking about whether or not to try one of these diets keep in mind especially if you're young you know these diets none of them even these fasting diets that are supposed to be easier are perfectly easy and you might want to just support research into some of these other things and hope that you can bring about their arrival sooner thank you so this I hope you read that these are the variants of dietary restriction so you can restrict particular nutrients micronutrients macro nutrients of sources of energy which is basically fat carbohydrates and protein alcohol would couches them forth but I think most of us know maybe not in Sweden but most of us know we should restrict alcohol at least to some degree and then we have traditional continuous dietary restriction and then limiting food intake to certain periods and that could be done in all kinds of ways you can eat with at a window during the day either earlier late there are all kinds of different day or two day fasting regimens and then these longer fasts I need to say one quick thing about the importance of isocaloric comparisons because a huge number of studies have looked at particular diets and there's either no control group at all or the control group wasn't eating the same quantity of food and what that means is that what can arise is this problem of what we what we call crypto cr1 one quick example is these early vitamins C's studies vitamin C is bitter it doesn't taste very good you mix it into the food or the water of the experimental group in a mouse study they're gonna eat less it just doesn't taste that good maybe only a little bit less but then they will live longer but it's not because the free radical theory of aging has been confirmed it's just as they're eating less because the food didn't taste as good you and this applies to ketosis and ketogenic diets in particular now I actually believe in ketosis and I believe in the power of ketones for a variety of reasons but I don't think it's the evidence that they're as miraculous as some people say is pretty thin because so many of the ketogenic diets the diet studies have been done with either no controls or controls that weren't done very carefully and it turns out that on ketosis or on a ketogenic diet you will lose weight and so you don't know if it's the CR or the ketosis that is causing you seeing benefits so imagine just by way of analogy I came up with a crazy diet the taxonomical name letters rearrangement diets where I'm going to only eat foods the taxonomical name for which has letters that I can rearrange to form let's say ex-girlfriends names so I go into the kitchen I don't thinking okay I want have some broccoli okay that's brass is I can eat broccoli and every time I have to eat I have to through this complicated process and I get my baseline tests done in three weeks later I get much some more baseline tests done and I see my fasting glucose has improved my cholesterol has improved all my biomarkers have improved dramatically I started blog about the taxonomical name letters rearrangement Pinta girlfriend's ex-girlfriends names diet I write a book people are debating what the real mechanism is is it that I'm learning a new language because you have to little bit of Latin and BDNF is going up in my brain and aging is centrally controlled so that's cosmides or is oxytocin because these women are so wonderful and that's making me age what is it that's happening obviously that would be absurd all that's happening is I'm going on CR and that is kind of what I feel when I'm reading a lot of these ketogenic diet studies so we have to be really careful to look at every study that you're trying to assess and see whether or not there was weight loss and if there was was can you interpret the result as being attributed to the independent variable of the in the case of ketogenic diets ketosis and there's this another problem related to this isocaloric comparisons are very difficult so even if you had a diet that was a ketogenic diet let's say a very high fat diet that was mostly nut based and the control group was didn't have a lot of nuts but but you measured the food out so it was the same number of calories in each group it turns out the database for the flora content of nuts is completely wrong it's basically overestimated so the the true amount of calories and nuts according to this study is probably 32 parts the amount listed is 32% higher than the amount given in these nutritional data sets so all these people that haven't know a lot of us here on CR using these programs like chronometer to measure our caloric intake like I've been surprised at how many calories I'm eating sometimes I eat 25 2600 calories but my diet is about 95% by calories nuts these days that's somebody not say eat so obviously it's a gross over estimate estimation and now I know why I haven't gotten fat because I'm actually not absorbing as many calories from the nuts for the meeting alright micronutrient restriction I'm gonna zip through some of this I just many of us have heard of the earlier methionine restriction studies that lengthens maximum life span span in all kinds of studies in rodents and branched chain amino acid restriction can lengthen lifespan those studies are a little bit newer obviously restricting saturated fatty acid can improve biomarkers and probably even particular saturated fatty acids should be restricted like the ones found in meat and then plummeted acid found in palm oil methionine restriction and leucine restriction appear to work through slightly different mechanisms which is very interesting both are very high in non vegetarian diets it but in other words in meat so that would be an argument for eating a vegan diet Metheny it's not clear exactly how that works but it is clear that leucine restriction probably works by lowering mTOR signaling um lot of well-known diets like the Mediterranean diet probably are micronutrient restriction studies unintentionally this is a nice summary by Luigi Fontana at all about the Mediterranean diet and he concluded that a lot of the benefit probably is from the lack of meat and there are a lot of nuts of course in the Mediterranean diet which means that branched chain amino acids leucine I've seen and isoleucine and valine are restricted and my finding and cysteine are restricted as well and then of course I note that it's a restriction of a lot of the fatty acids found in meats the saturated fatty acids all right I'm gonna go through this fairly quickly I think most of you know about this low-fat diets were in vogue a while ago and I think they actually can help Dean Ornish did some great work there but all of his studies involved reduction in proteins as well as you can't figure out whether on it was the lowering of the fat or at the lowering of the protein low protein diets now it's clear are very helpful for the improvement of age-related biomarkers in humans and can lengthen the life of laboratory animals just a quick note some of you may have heard this seen these studies or read about these studies mostly done in the UK where vegans are smarter than non vegans when they're younger and that reverses and that scared people they didn't know quite why that was so it it turns out we don't know it's probably the case that it's a lack of dietary creatine so if you're a vegan supplement with creatine low-carb diets this is really in vogue and there are all kinds of benefits but it's not clear how many of the benefits are going to involve retardation of the aging process and there are almost no isocaloric studies they're a couple but they're pretty short-term so there is excellent evidence that ketogenic diets can control epilepsy it's been used for that purpose for a couple decades there's pretty good evidence that it can benefit neurological disorders and as I said they're only a couple of studies they're really well done showing improvement in markers of Aging in humans they're improving in other markers and other conditions but not marks of Aging and by the way if you want to try this a ketogenic diet cannot be high in protein because I will kick you out of ketosis by the way an amazing thing this I learned at this conference it's not published this guy I'm Jose Roberto Trevino Villarreal at Harvard did this study that was protein free and it had 90% simple sugars but nonetheless it made the mice go into ketosis so astonishing all right so now we'll get into the limiting food to particular periods time restricted eating that that term is used in different ways sometimes it's used exclusively to restricting feeding or eating to within a 24-hour period but here I mean it broadly there are a whole bunch of things to keep in mind when looking at the research it's the research in humans is very new there's very little studies very few studies involving ISO chloro controls most of the studies in humans are weight loss studies and that means that it's typically subjects who are overweight which means they typically have metabolic syndrome or type 2 diabetes and the the work in mice doesn't always apply to humans especially when it comes to the narrow eating windows within a day because they're nocturnal so it's hard to know how light affects the circadian clock since they're active at night and how that would intersect with eating windows that butt up against different parts of the circadian cycle and then the most important problem is that a day for a mouse is many days for a human there are strains of mice that if you fast them for about three or four days they will starve whereas even skinny a human can fast for typically 30 days there sorry it starved to death in 3 or 4 days this picture which I hope you can read i'll just read through myself the important points is what to keep in mind when considering different lengths of fasting in your own practice and note that if you're on any kind of continuous dietary restriction those hours that I that I've written up there are greatly accelerated so you eat food and then you're in this fed state where blood glucose is going up and you're creating glycogen and then when you get to about if you're not on CR dietary restriction maybe you know an hour 18 or so you get into the so called post absorptive state where the ptosis sort of begins and that's what people who are doing this hope that if they have a narrow enough time eating window that they will at least have a little bit of ketosis towards the end of the non eating period and if you're on CR you get into that state not of our 18 but I would imagine it's probably our eight or nine if you're on really severe dietary restriction and then you get into the fasting state where you definitely have ketosis and then finally in the starvation state you're in an extreme state of ketosis and otology it really should be pronounced Auto if AG to make it easier to understand what it is this the the eating of itself basically it's the cells recycling of internal components that are damaged so I'll call a autophagy now auto if AG kicks into really high gear when you get to about the two or two-and-a-half day mark now it turns out it varies by tissue and we haven't really studied this very well because you would have to do biopsies but at least in many tissues in humans it kicks into high gear after two days or maybe a little bit more so let's go into daily time restricted eating so this is daily time windows that a lot of us follow very very few studies have been done but a really good one it's in obese men but a really good one is done by this team that I think is ultimately led by Courtney Ann Peterson but there's some other Eric Radisson is the senior member of the team but she's kind of taking control of this she went into this at a big conference I was at in November on it was organized by ultra long go on various forms of restricted eating and longevity and here this was an isochoric study and it did improve compared to the other group that also was eating less it did improve these measures and the reasoning was for the design of the study that if you get out to you know something like quite read that with my bad glasses if you if you have dinner early enough you will have this very long period about 18 hours before your next meal and the theory was it's not just ketosis but there are all kinds of things that start to happen when you go that long without food and that that would have distinct changes or metabolic advantages compared to eating less but having be more spaced out meals I just wanted to show that one more time so so again the highlights it increased insulin sensitivity improved beta cell function lowers the desire to eat in the evening I personally have not experienced that but I think I'm still might my overall amount of food that I eat is still I haven't gone fully off CR so I think I'm always a little bit hungry so summary it can improve health even in the absence of weight loss so it's something about just rearranging when you have your food so that's a significant finding but again it's overweight and if slightly overweight and in some cases part of the same group very overweight obese men and it's not clear that that would apply to many of now at the conference I asked her I asked Kourtney Peterson if she was because in a way her study has two independent variables there's the restriction itself and the fact that it's early and since so many of us don't want to avoid going out to dinner with friends we want to be able to eat at 6 or 7 or with some friends 9 p.m. we would like to see a study that has a narrow time winner this later and she is in fact arranged gonna study like that it's gonna start enrolling I think now now so we'll have results maybe preliminary six months from now but she and others suspect that it might not be as good as early time restricted eating and that's because the circadian clock is governed in all kinds of different ways there's the central control of it that's linked to light mostly but particular organs and tissues and actually be entrained to a different cycle based on what you eat so if you eat late at night you know your liver might think it's morning but your brain is sending out signals that it's night and that doesn't have to be a problem but there is some evidence again in overweight men mostly or some overweight women that it's actually not such a good thing and there's plenty of evidence that the body is more able to handle food early on you know pretty much right when you awake or close to when you when you wake up up to about 3 or 4 hours after you wake which is too bad because I actually would love to be able to eat later because it helps me sleep oddly I'm going to bed with a full stomach it's the opposite for most people the plenty of people are doing you know one or two day fasts pretty frequently I've started to do that actually partly just because sometimes like today when I've been really sleep-deprived I just don't eat and it helps keep me awake like you know I drink so much coffee but there still isn't a lot of evidence that for normal weight people there are going to be benefits to this kind of fasting and lots of researches is underway but we don't have solid evidence yet this one you amazingly nondeterministic many of you have heard of Valter Longo 'he's fasting mimicking diets it's called fasting mimicking because it's not zero calories it's actually a huge number of calories the first day is 1100 calories and then Days two through five are around 700 but even with that much food apparently it can mimic the effects of fasting and there are astonishing benefits but there's no head-to-head comparison with an ISIL or control group and there's no long-term evidence of benefit I mean it's pretty clear if you don't eat that much for five days your blood pressure will go down I've done the experiment you're fast and glucose goes down you have all kinds of benefits and it and they maintain themselves for a few days not much longer I asked him why he didn't do a head-to-head comparison with an icepick Laura control group and he said well the people in his study gain their weight back so it's not needed but that doesn't seem quite right to me because obviously when they're on the fasting limiting diet they have a new equilibrium so overall they actually are eating less so I would like to see a study where let's say that in these five days people eat that Guinness would be about 6000 calories it's less than normal it would be 200 calories per day per month if you average it out so just have a control group eating 200 calories less per day I just see what it looks like six months later and he hasn't done that yet we get stories like this all the time fasting really is amazing but we don't know is again whether or not if you had a group of people losing as much weight as people do on a on a you know long-term fasting diet whether or not they would get the exact same benefits and that really needs to be studied and then there's this crazy idea I mean there are there are people in the CR Society who go on seasonal extreme CR and I actually considered doing that once but I thought it might be a little bit a little bit too risky but you just have a lot of work to do you just sort of like people who take a high dose of a statin to radically lower their LDL kind of clear things out a little bit for a while and it might be dangerous to do it for five years but do it for six months it's not such a bad idea but but there were people who do that a quick thing about metabolic flexibility that a lot of us have heard about metabolic flexibility is important it's the ability to adjust to changing energy demands because of going without food or perhaps exercising more that is really important and there's this idea that we need to I hear this all the time from people on various forums that I'm connected to people who email me wondering what they're doing whether or not what they're doing is a good idea that we have to change our temporal eating patterns around to somehow teach our bodies how to be flexible on this not pollak way in order to sort of keep our flexibility in good shape there's no evidence for that at all this that's based on the idea that when you have very overweight people fast periodically they lose weight and they do become more metabolically metabolically flexible but that's because people who are overweight aren't metabolically flexible so they lose weight by any means it could be by fasting periodically or switching around their temporal eating patterns but when they get leaner they become metabolically flexible so practical conclusions I would say a reasonable decision tree would be do you want to simply not think about food and wait for our age of Ursula Network or maybe the Sens or some other group to find or validate in effective ways to reverse aging if you don't want to wait then I would say the first thing to try because it's been researched more than any other form of anti-aging diet is normal continuous dietary restriction and do it in an extreme form I can say most people probably don't want to do that I just say from experience doing it myself and talking to lots of people it's just very rare for someone to want to do an extreme version of CR if you don't want to do an extreme version of C R or D R then I would say try these various versions of fasting and I would say D the fasting every I don't know we depending on how long you do it if it's gonna be maybe two or three two or three days which i think is necessary to have a toffee or Otto if AG kick into high gear if you're gonna go that long you don't want to do it every week that's probably two to freako and I would say every ten to fourteen days that's what I'm doing now I decided that actually a couple days ago in preparing this talk having read through the research that's I'm not going to do severe continuous dr cuz i just did it for too long and it was being a functional unit just it's not that fun um if you don't want to do these you know two or three day fasts then i would say stop eating as early as possible before bedtime so do this early time restricted eating and keep an eye out for the research of courtney peterson group which will report on our on our website about the late time restricted eating which i think is more appealing to most people and i think that's it Thanks I'm gonna switch microphones and do it great so if you have a question for Brian I'm going to bring the microphone to you so that people online can hear your question we have 35 people all over the world in our live stream tonight Jeff you have a question how do you deal with the irritability and weakness that goes along with not eating much you know you know different different people experience that differently some people don't experience it at all the weakness is something that usually goes away I mean I assume you mean fatigue not the kind of sarcopenia or something that that typically goes away where people can adjust that the irritability I don't know if that goes away I mean it's you know III joked about the I didn't really joke about it but they noted the curious phenomenon that the some species of mice have to be caged individually because they're so hungry they will cannibalize their cage mates my girlfriend of the time was was looking over my shoulder and I was reading that report and for the couple weeks after that she kept asking me if I wanted dessert after dinner no but but apparently I was somewhat irritable and I didn't even know it so I that's that could be a problem I have a question from Leonid I'll bring the microphone back to you in just a minute Leah no no recently I read an article through Harvard med school when a story made in France concerning the what they call a prologue station diet they say a method was on three days a week and not having any food up to the dinner time they did the story in people having diabetes and it was a short story but all of the diabetic patient when out of the disease in a short period of time I have two questions do you have in your experience any diabetic patient who has benefit from this diet and if not those who has no diabetes do they have any significant drop in the blood sugar levels thank you thank you yes we do have experience curing type 2 diabetes not type 1 but type 2 diabetes with with sufficiently restricted diets that happens all the time if there's one thing that you could be certain of if you eat less your gluco regulatory markers will improve so anyone who I have not seen anyone in our society go on any significant degree of dietary restriction without having lower fasting glucose usually lower insulin lower glycosylated hemoglobin so that's a that's a pretty constant finding one yeah I just wanted to say about the irritability the gentleman said something about being irritable I've been in 14 different 14-day diets and the month-long diets and fasts usually meditation helps with that if you do fuel urges or like the meditation also that also I do recognize the help and if it's so fasting and I'm really happy that you're doing this thank you so much thank you thank you thank you you know Neil let me say one more thing when it comes to fasting even though I'm I'm my initial interest was in the potential for age reversal as opposed to curing of various pathologies that aren't directly related to aging and if you you know I noted that there are some problems with a lot of the studies looking at potential reversal of a gel of versatile aging I still think that there are other benefits to fasting and when it comes to irritability with with fasting I actually love fasting there's the kind of 2 day hump before you've gone into enough ketosis to for your brain to have energy but once you get past the second day the irritability seems to go away so that would be one way it's all those downsides that I listed the the notion that they but I wrote at the bottom that they might not apply or they might be more manageable with other forms of dietary restriction I think that's really true if you compress your non-eating make it more intense are you fasting or near fasting and have it be just five days a month there were seven days a month or two and a half days every 1014 days then you're really not irritable at all when you're not fasting and then you go into this fasting state you're really or I am anyway really irritable the first 24 hours because you're really hungry and then you kind of go into ketosis I try to distract myself I have a day of errands or something on the beginning of the second day and then the irritability goes away question over here okay so I've been practicing intermittent fasting in dietary restrictions I think since I was 19 and I think one of the I can attest to the benefits of it up across many different levels of wellness both emotionally physically mentally the clarity that you get the energy that you gain but I think there's one factor that I haven't heard you bring into the equation and that's the factor of hydration I think that's key so maybe you can touch on that a little bit for the group sure you know it's funny one of the members of the CRS Society thought that water restriction with lengthened lifespan and he had two rats that he kept in his apartment one that was on WR and the other wasn't and there was no difference in lifespan but but hydration I mean I think we some of the studies have shown that this idea that you have to eat and drink eight glasses of water a day that's an exaggeration you really don't need to I because of for various reasons partly I discovered I'm prone to kidney stones I have to drink a lot of water but it's not a good idea to drink a huge amount of water or really much water at all or any liquids right after you've eaten because it kind of dilutes your stomach acids and can you know cause reflux so I because I compressed my eating certain windows I'd actually don't drink water at all during the time that I've eaten and maybe an hour or two after and then I drink a lot of water so I don't get another kidney stone which was known as painful experience of my life so yeah okay just to address the formula that you just provided I was taught by my mentor many many years ago that and I'd like your opinion on this that the proper formula of hydration is to drink half your body weight in fluids not to exceed 90 ounces a day over the course of the eight-hour day every 30 minutes consuming for instance if a woman is consuming is hydrating she would drink 4 ounces every 30 minutes because the liver has capacity to process 4 ounces every 30 minutes and a man would process up to 6 ounces every 30 minutes to consume half your body weight in fluid on so if you weigh 140 pounds divide that in half you would consume 70 ounces I was gonna say 270 pounds of water that's a lot but no converted so it would be you know half your weight in fluid ounces so 140 pounds 70 ounces of water a day divided up into equal increments over you know 30 minutes 30 minutes cycles because the livers supposedly flushes every 30 minutes and reproduces the amino acid chains etc in that timeframe and providing the hydrogen and oxygen to primary elements that the liver needs for proper cell production so what's your opinion on that well I think I mean I do think drinking or drinking water after there are some studies that show that drinking water we always have to have water with meals that there's 30 minutes thank you I'm sorry I didn't clarify on that I wanted to touch on that point that you mentioned you wait 30 minutes before your meal you you with hold water for 30 minutes prior to your meal and 30 minutes after your meal so within an hour's time you're consuming your your proteins fats what-have-you but eliminating the water for the 30 minutes before and after well it sounds logical it sounds like an appropriate amount of water to consume you know for me I've been after I would I would wait a little bit longer after finishing eating I really want the food on its way out of my stomach and it's it's really because I have reflux and it sort of mix water with with the food make the reflux worse but otherwise it seems sound I have a question back here Judith what are ketones I've heard you mention a lot there was uh they are well one is beta-hydroxybutyrate that was the thing in blue that the Greek letter ADA Oh a hydroxy BB rate there are sources of energy that are it's it's it's an alternative to glucose at most that many tissues can use including the brain so they they are the primary source of energy if you've been fasting of a long time and the body doesn't have a lot of glucose available and doesn't want to use up muscles and convert muscles to glucose that's right that's right so through fasting you develop Keystone's is what it's being yeah yeah yeah I take it fairly aggressive approach myself like I'm buying tre I just had breakfast about half an hour ago downstairs nighttime tre with that Foreman and um are your thoughts on combining CR by medics light met metformin and tre is that overkill or is that perfectly legit didn't you doing you know I think it really depends on the degree of each you know if you were taking a huge amount of metformin you probably wouldn't need to be on much dietary restriction or you know timers things it eating if you're on I think if you're on really extreme dietary restriction metformin would be would be unnecessary and it could it can be harmful but that's only if you're on a really the same thing with rapamycin you wouldn't need rapamycin any any CR a dr or lifestyle emetic as I'm calling them is not needed if you've really radically optimized your eating and exercise so you know if you I don't know if you if you've let's say lost 30 percent of your body weight since going on this diet then you probably are on a pretty extreme version of dietary restriction and then you might not need metformin but I don't know a few fifths you think you've taken it that far no so you so yeah if then I think the combination is is actually ideal and you might not want to take 2,000 milligrams per day of metformin but you know maybe 500 in the morning and 500 and evening Merson from Kenneth Oh both my wife and I have been on extended water fasting six and a half days and myself 17 and a half days we did notice on the water fast that assuming somewhere between around 32 to 35 ounces of water a day was all that we could actually consume but I'm curious because I met people that were on much more extensive water fasts a month six weeks how do you how do you feel about that even a two week you know the there isn't enough evidence to be to be totally honest I what what I would say is what we do know based on animal studies is that the older the mouse it's usually my sometimes rats but usually mice the less able they are to handle radical and rapid those are two different things but both are true changes in their diets that's been shown that if you did because it was a bit of a puzzle to researchers why and the reason the reason that people weren't advocating that humans try calorie restriction when it was first discovered to the slow aging basically a century ago it wasn't Clive McKay in the thirties it was actually twenty two decades earlier that the first real study was done the reason that people didn't say humans should try this is that shortly thereafter I think was the 40s Amira's a little bit late nura 50s people tried to institute 30% restriction in adult mice and they died younger and it got people wondering you know well why is that and they tried to figure it out but they basically gave up on that on the idea that adult humans should try this it but wasn't old Roy Walford came along and there was a couple other people who said well let's try let's assume that that adult beings can't handle radical changes like that because 30% all at once is a pretty big change let's institute it in phases so you know a third of that 30% month one and then the second third month do the third third month three and they live longer I bring that up because that's just one example of the ways in which older mice at least that almost certainly applies to humans in some way can't handle radical changes so I'm 55 I think if I suddenly stopped eating and only drank water and did that for the 30 days that seems to me risky if I were 25 I think it would be less risky the body is very adaptable I'm not 85 55 is not that old but it seems to me that that that's a little bit of a risk 7 or 8 day water-only fast that's still a little bit of a risk but that seems to me as long as you're still in some body fat you know a significant amount seems to me that might not be quite as dangerous by the way one of the things I like about a vault or Longos concept the reason that he came up with the fasting mimicking diet is that he thought it would just be easier for people to have a little bit of food to eat and they at least they have their little breakfast their little lunch another little dinner instead of nothing but there's an additional benefit to that and I'm gonna be kind of evolution theoretically speculative here which is always dangerous but it strikes me that it would be odd for natural selection to have required that we be able to handle zero calories for an extended period because during a famine which we natural selection would force us to be able to handle there's a little bit of food somewhere always there we would be eating little bits of leaves we'd find something we would never eat zero calories so what I fast it's scared court fast it's not this you know 1,100 and then 700 calories of Valter Longo his diet but when I fast I will have a couple hundred calories usually leafy greens of some kind of ruler or salad very very low protein I'll have a just a bowl of lettuce because it seems to me that zero food that would not have been something that our ancestors would have had to like for days and only water would not be something that we would be naturally adjusted to hi Bryan is there a way for us to measure the center lit excels there in our body so we can develop a baseline when you're doing those biomarkers to see whether or not we would have improvement if we do that as a native Corsican study great question and really important question there are there is one established way but you can't you can't order it as a consumer yet it's called senescence associated beta-galactosidase and it's something that is is elevated when you have more senescence cells so you can measure it you take the SATs and in quercetin measure it again and it should go down if the NQ worked but there are a couple of teams that are working on other ways of measuring this there's a there's a group at UC San Diego I'm actually I've donated my blood and I'm gonna do another round of cinematics I'm doing too many perhaps but just to help the science and they'll do a before-and-after test looking at a whole bunch of different markers they have a whole panel of making sure I don't see anything I'm not supposed to say well they have no Pamela of markers that they're looking at and and we will know whether or not it works I think within a couple of months and then I don't know if they're gonna commercialize it but it's very promising and I will I will put it on our website when whatever I'm allowed to say when we have the results but it's a really important question because otherwise I mean we do this most of us know if we're older than I don't know 45 or 50 we should probably do some static treatment but how often do we do it you know we don't know unless we can measure the results and measure senescence Elberton question from Carol what is your opinion of the low fodmap diet for irritable bowel syndrome you know I looked into that because I was told I might have IBS at one point and maybe I did I'm not sure it was it was actually right before actually it's funny I mentioned the surgery I had I had I had a hernia inguinal hernia and three years ago and I may have gotten it because of IBS because I had so much bloating I'm kind of I'm not a doctor but it's logical I sort of felt pressure after eight and I was eating that's before I went to my you know massive quantities of nuts diet I was eating a lot of vegetables and and I wasn't done extreme CR so you know if you eat a lot of vegetables that's a lot of bulk and I was trying to eat within a narrow time window so I was sort of stuffed and I had this load feeling long after a food should have been digested it should have moved along so I looked into this fadh2 map diet and the research actually looks really promising and I was I was going to try but then I had surgery and went off CR by eating all kinds of junk and then decided to eat nuts and nuts did not bother my god so I if I had IBS I don't happen anymore but when I looked at the research had looked it looks quite solid you know it's still preliminary but it looks very good hi Lee oh I know well you put if you look that mean the team that started this research is in Australia and they I don't think they're if they've committed they've they're just pure researchers and they're they've done really solid work yeah I think I think it's a it's a it's still new but I think it's a pretty good idea you bet Brian we have a question online from someone I believe it's incoming from Columbia perhaps but it's from Manuel and the credit and the question is I do fasting for two days a month I work a night shift I eat every 12 hours and eat vegetables my question one of these two meals is one of these two meals is right for bed as this beat the purpose of healthy eating that's a really important question and it's really important for me because I mentioned I have these horrible sleep problems and unlike most people I can solve them by just eating a huge amount of food or like if I if I can eat all my food right before I went to bed I would sleep perfectly and and you know if I could get all the benefits of having the narrow time window that I would get had I eaten that food early and that would be perfect the fact is we don't know but but as I said there's reason to believe it's not that you would defeat the benefits I asked Sachin handin this question he does he wrote a book called the circadian something-or-other given a couple of books about the circadian clock [Music] asked him if I had my narrow time window of eating very late at night what I still get the benefits and easy he's one of the people who believes that ketosis is what really matters I'm not sure he was right about that but if ketosis matters it doesn't matter when at the time window is because you'll still have the long period of not eating and you will go into ketosis so if he's right what he said was you'll get 18 to 90% of the benefits so that's my answer to Manuel that it's not defeating the purpose according to the Sachin pandan and I think such an pandan might be right my feeling would be that he's getting the some of the bend of benefits but that it would be better to be eating earlier if he can every question here well I had the opposite situation I just lost a lot of weight and they went down 297 pounds thank God I've taken but it's putting some back on but you mentioned creatine and I just looked it up and it has a way of now giving you water retention and building muscle and body mass but do you have to do the resistance exercise because I'm really I don't really go to the gym for that can you take that and just do your regular routine of exercise it would benefit you if you I mean if you eat a lot of meat you wouldn't need so much creatine okay well then I would say you you you want to I would say would be a good idea to supplement with creatine you know maybe only a couple grams per day maybe to begin with four or five grams per day for a week that's a lot of people would recommend if you do resistance training you will get more benefit and there you know plenty of the studies that show that as we get older we do want to do resistance training there's even this amazing study that came out recently we all know that aerobic exercise is good for the brain resistance training is good for brain in different ways different parts of the brain so I would I would say if even if you don't go to the gym I don't go to the gym right you know I have my backpack I containers of water in it and do you know I mean there are all kinds of things you can do at home just to use your muscles in a resistance training kind of way I would recommend that Ryan do you recommend taking creatine if you're eating fish I I don't think you would really need to there's a question for Mario I didn't get clear that after three days of fasting why would you get almost the in Juris amount of energy well I wouldn't say it's dangerous but that it's and it's not so much compared to baseline but it's compared to a the end of day 1 and day 2 of fasting where you don't have a lot of energy because your body is running out of glycogen so you don't have a lot of ways of getting Lucas elevated in the blood without using using a protein your muscles which the body prefers not to do but you haven't the body hasn't yet started producing these this alternative fuel source these ketone bodies so so it's not a huge amount of energy but you have more energy than you did after that lull in day 2 and you really die I don't know if others who do a fast experience there's some where on day 3 suddenly it's like yeah yeah it's amazing krakozhia question from rich Ryan one question you mentioned ketones the value of ketones the benefits support ofuji or a tough year and it's good for a thought processing etc and shedding sentence analytic cells you comment on adding beta hydroxy butyrate or which is a ketone through your diet absolutely I actually do that too precisely to get over the day to hump I even buy this powder basically tastes horrible no matter what they say about the miraculous flavoring they put in it just tastes horrible but that's okay it's worth it so I take it actually today is I'm fasting today because I just haven't been sleeping and the fasting helps keep me awake because so before I came here I had 14 grams and that's about as much as you can absorb at one time when I'm what I'm doing a longer fast I won't have any on day one and then on day two I'll have eight grams about every two hours and that seems to make a difference to me but there are studies that show you just don't absorb that much that's why you know we've talked about this the intravenous ketones would be would be one way to really boost ketone levels dramatically I'd have another question from online and one of the viewers on the live stream asking named Ron since you healed colitis did you use the help of butyrate Slyke try butyrate it seems to be protective of the lower GI a great idea no I did not by the way it was Crohn's disease not colitis but it's similar um no I did not but but plenty of people do and there's some research showing that that can help I have a question from rich hi there is there an average life extension benefit the calorie restriction and number two if you do restrict your calories can you restrict them too much and kind of cannibalize your heart muscle and things like that your first question is is there an average extension of lifespan it will in my certainly and it tends to be attends me you know it depends on how much you restrict but you can if you did the earlier you start the more you can restrict so if you restrict it weaning which a human would typically not want to do it can live 50% longer most species of rodents for humans we simply don't know it could be it's it's really hard to tell because we don't know exactly what the non dietary restricted maximum lifespan of humans is as I was saying it's not a hundred and twenty I would be certain of that I think when you interview these people who have lived two very long lives they they tell you that they you know eat a lot of chocolate and they drink a lot because they want to attribute their longevity to something intrinsic not their diets but in a couple of cases researchers have looked at what they actually ate and they were anal retentive vegetarians I mean they they so they just spin these stories so that it they seem to have this special power to live longer so I think the non-restricted human maximum lifespan probably is not so far from about a hundred if that's true and these people who have lived longer have been on unintentional dietary restriction for stretches of years during their lives and I would say you could get a benefit of maybe 20% potentially we have one last question from Robert yes I you mentioned you lowering protein is part of the regimen what does that do to your muscles you know in other words have you have you experienced muscle loss and is proteins yet that reminds me it didn't answer Rich's second question away which obviously is connected you can take dietary restriction too far and of course you will you will start your organs will start being eaten up the brain is spared I mean different my studies where they put them on extreme CR and the brain is the last to go with protein restriction you can get to a point I mean it's really it's hard to know when but certainly if you restrict it too much you will start losing muscle mass but but that will happen it for your restricts any source of energy you will lose muscle mass so and then there's this one study that came out that cited frequently among people who are worried about the dangers of starting CR or taking it to an extreme as they get older that showed it was not a really well done to study but it showed that as we get older we have to eat a little bit more protein I'm not I'm not convinced I'd like to see that study repeated but I would be I would be cautious I would not want to take protein restriction too far and turn ative that a lot of people are actually advocating scientists would be that you have kind of high-protein breaks from an otherwise low protein diet to let the body rebuild because it wouldn't take that long and it usually - people call it as sort of famine is the norm and feast is the exception and then you build everything back some people reverse that that's what Valter Longo is fasting mimicking diet is feast is the norm and then you have this famine for five days every you know month - I appreciate that question but tell you what we're going to do you know Brian's going to be here and you'll be able to ask him some more questions I know there are more of you that have questions but we're going to have them available for you to ask questions directly and in person here downstairs after the event tonight so let's give a big hand to Brian Delaney thank you for being here dr [Applause] Thank You Bryan you know you may not have been able to see his PowerPoint presentation but that will be on our website so you'll be able to look at that later on and we're going to get it on there by next week it'll be up for you to to see now the man who's made this whole facility possible the whole evening possible the founder of Perpetual life let's welcome mr. Bill faloona bill well good evening group I want to travel back in time to year 1997 1998 I had many many conversations with a very well-versed member of our group and he continued to enlighten me that the secret to controlling aging lies in our bone marrow that as our bone marrow ages we age systemically and if we can do anything to reverse the aging process of our bone marrow that's where our stem cells are produced our immune cells all of our blood cells actually in the bone marrow if we can do something to reverse that then we're going to be able to dramatically slow and/or reverse aging that was 1997 1998 the question we both asked each other is what do we do about it how do we make that happen and then good news is there are some ways to potentially make that happen now this particular slide is from my last week's presentation last month's presentation done on January 24th and it does emphasize something though that I should reiterate and that is as we move towards the very aggressive types of interventions designed to reverse aging let's not forget the basics basics involving hypertension lipids glucose triglycerides homocysteine the ways that we can improve our health that everyone agrees on we don't want to forget that foundation so that we can then build on that foundation to the second level but let me ask the people in the control booth to put on the presentation for tonight because this is the presentation I did On January 24th and but I can talk a little bit about what we're going to talk about and that is bone marrow health something that is a challenge at this point but a fascinating study came out just last week published around February 20th in which they took bone marrow from young mice and transplanted at bone marrow into older mice and the result that they were able to measure definitively was a significant improvement in neurological function it could memorize better learn better there was an improvement in their brains capacity to function and these were old mice transplanted with young bone marrow now this was not surprising to us because we've been studying this for a long time in fact in 2014 we launched a fundraising campaign to see if we couldn't do a study it was gonna cost about 10 million dollars and we've not raised the money by the way to see if we could mobilize the bone marrow of very young people and put the stem cell mobilized plasma into older individuals we are still trying to raise funding for that particular study but to give you an example as to how well this particular research project worked you look at these four diagrams of the microglia brain cells now the graph or the chart the cell they're to the far left is a healthy young microglia cell and you notice it has branches extending from it those are synaptic connections that enable that microglia cell to communicate with other cells and how our brain works by the way is like a parallel processing computer where you have perhaps very slow microchips all linked together in such a way that they communicate so effectively that that computer operates very fast which is how young people think they think fast they learn easily they memorize readily but with aging and that the second microglia cell you can see those branches have shriveled meaning that the cell may maintain some functionality but it's no longer connected to the rest of the brain the way it was and then the third slide over that was an old Mouse given old bone marrow transplants bone marrow from an old mouse transplanted in an old mouse that was essentially the placebo it shriveled the connected the connections of synaptic connections they just continued to shrink meaning that old bone marrow is probably toxic we have a lot of a lot of evidence but the fact a cuter slide to the far right of that screen those were old mice with young bone marrow transplant it into their bodies and look at how those connections sprouted essentially that old microglia cell in the brain resembles maybe even exceeds a young microglial cell this is hardcore evidence and that's the only cell they were able to really electron microscope but they were able to validate that in response to those branches regrowing from the microglia these mice were thinking and performing as younger my mice so that conversation I had over 20 years ago it had a lot of significance especially when I saw this type of study coming out just last week in the published literature in fact most of what I'm going to talk about is what's happened over the last 30 days that's how fast the science is evolving a heart failure affects about 8 million Americans some of the statistics say 5 million the real number is 8 million and it's going to increase it occurs when our heart muscle loses the ability to pump and oxygenate our whole body with sufficient quantities of blood and most people with heart failure they die relatively soon well the interesting factor about heart failure is depending on where you live determines how long you survive with and Jeff of heart failure now if you look at this map South Florida is one of the healthiest places to have heart failure you are you're less likely to die in South Florida than you are in Mississippi Louisiana North Texas Oklahoma those dark red spots are the highest death rates from heart failure now does it have something to do with the climate I don't think so no no it has something to do with the quality of medical practice and the lifestyle practices that these people engage in think of people in Mississippi Louisiana North Texas Oklahoma the tobacco use the obesity the horrific diets that they engage in the lack of exercise these are areas of the country where people are not taking care of themselves so when they're diagnosed with heart failure they accelerate the rate at which they're going to die whereas people in the Los Angeles area of California New York City South Florida they have a greater understanding of what they should be doing to take care of their own health and they also have better access to cardiologist who know how to treat heart failure better now this is data that I presented before it is remarkable starting in 1995 not that long ago and going to 2014 a 44 percent decline in sudden death rates in heart failure patients that's the market improvement over just 19 years now some of that technology is conventional medicine this is what enlightened cardiologists are prescribing to heart failure patients it's a cocktail of medications that improves survival rather dramatically and if you ignore this type of technology even if you take a lot of nutrients and do a lot of other good interventions you'll probably dud die sooner so we advocate the people with certain disorders follow conventional guidelines and then move in to alternative medicine to derive the benefits of both and I people who approach me with heart failure and they say I've never taken a drug in my life I don't want to start and I say guess what if you want to leave you're probably going to start on four or five different drugs and you're gonna take them all during the course of the day and you're gonna start on some nutrients we're gonna replace your hormones you're gonna change your diet because that's how we can enable you to live a lot longer this is technology and action resulting in 44% fewer people dying of heart failure over a 19 year period it's rather rather dramatic now the new intervention has just recently been discovered is that Sinnoh lytx may be an effective way to additionally treat heart failure and for those who are just here and don't know a cinematix this is a slide I've used before a cinematic compound selectively destroys senescence cells these are sometimes referred to in the media as zombie cells you wish they would just die instead they linger and they're and they're highly metabolically active in a way that they destroy the existing cells so that those cells become senescent cells until you don't live any longer what senescence cells do is they impede organ function and hey your heart is one of those organs that senescence cells impede they create systemic inflammatory reactions 24/7 senescence cells ignite inflammation throughout your body and the scariest thing about what senescence cells do is they emit protein degrading enzymes they're called metalloprotein ASIS and they degrade protein healthy cells in the area of a senescence cell become injured damaged and senescent themselves so if you wonder why a sin oolitic drug or scintillant a compound might be an effective treatment for a heart failure think about senescence cells and an old heart and they're emitting these enzymes killing additional cardio sites and all of a sudden at some point your heart just doesn't work anymore you die well earlier this month results from a study came out showing that using sinha linux to remove senescence cells restored cardiac health in a mouse model of congestive heart failure this is a another medical breakthrough that's occurring more and more now on a weekly or daily basis I'm getting emails about new studies confirming or enlightening us to what we can do to protect ourselves against degenerative disorders and the media they pick up on that they talk about people at Mayo and other research institutes who are collaborating to show how removing senescence cells may be a way to systemically reverse aging and treat specific age related disorders like congestive heart failure so we're seeing the media pick up quite a bit and this is the charge from that study showing how the this cycles work where the cells emit certain toxic factors where if you block the senescence cells by killing them you're going to effectively treat ingest of heart failure so what we learned from this study published earlier this month is that in addition to all the other disorders that we know are associated with the accumulating senescence cell burden ingest of heart failure is another disorder in which we can potentially of a treat by removing the senescence cells from the heart and the rest of the body and again eight million people in this country suffering an urgent need for a clinical trial to be done using the proven similar two compounds that we've described before and I'm gonna reiterate what those are during this presentation and by the way this research all started only back in round 2015 about four years ago Mayo Clinic published a study showing that when they removed senescence cells from old mice all of these benefits occurred and if you look at number three they noticed improved cardiac function so the fact that they did a study using synthetic specific to treat heart failure in a mouse model shouldn't surprise us because it works in 2015 to induce systemic rejuvenation and JAMA September 17th 2018 reported on this research they described it as something that may transform medical practice where if you are a person over age 40 or 50 and you go to see a doctor he may prescribe a Sen oolitic drug cocktail as a way to at least alleviate whatever chronic condition you have and again reporting last month during our last presentation we talked about pulmonary fibrosis a kind of a disorder that you would think senescent cell renewal would be highly effective for and they did just a pilot study and they were able to show that that's attend ebb and course attend improved physical function it wasn't a cure but that was just the initial phase one study they're moving more into the Phase two arena now to see how efficacious they can make senescence cell removal treat pulmonary fibrosis a lethal condition normally kills people in just a few years that literally are not able to breathe and at rad fest September 21st I presented the first findings ever in medical history of a human clinical trial where we used a certain ebb and coerces in to treat people with severe bone on bone osteoarthritis 90% had significant improvement almost complete relief of pain improved joint mobility and we're just waiting right now for the follow-up MRIs to be read and interpreted in a way to see if cartilage regeneration occurred it is absolutely spectacular what we're consistently seeing in clinical trials that means trials on humans that emulate what's successfully done in the animal models so this is the Cinna lytic dose schedule that was used in the osteoarthritis study it differs a little bit from the Mayo Clinic study on pulmonary fibrosis and I think what we're using is a little bit safer and what I'm going to tell you in the next couple of minutes is how you may be to gain access finally to affordable dassit NM it's been a real handicap it's such an expensive drug because this used to treat cancer and because insurance covers it two drug companies mark it up way way too much and this is the difference in dosing between the Mayo Clinic study on pulmonary fibrosis and the osteoarthritis clinical trial that we helped fund they basically used a lot more corseted in our osteo arthritis trial and we actually used a lower dosing schedule desitin AB even though it looks like it's higher with a they used a lot of distant asset in that in that Mayo Clinic study more than what we think they may have needed now this is a slide that I've shown now probably to ten different groups that you can get assitant AB under a brand name called spry sole it is a drug used to treat leukemia leukemia patients take it every day and of course they have side effects by taking it every day at a low dose of desitin AB has not demonstrated toxicity in the clinical trials that we have been involved in problem is for tablets may cost you over $2,000 and you may want to do this more than once a year so the challenge has been finding a lower cost source now I was just informed tonight at a compounding pharmacist who's not just a pharmacist he's a PharmD he's got about as much education as a medical doctor but he chose pharmacy to get his doctor's degree his name is Allen Zimmer he's standing or sitting right in the front seat Allen just get up to let people know you're here he has vowed to identify and we're gonna independently validate sources of desitin AB that he will compound on an individual basis with a doctor's prescription of course compound the individual dose of desitin AB that you need to achieve the similar benefits that we were able to validate in our osteoarthritis study and what a lot of enlightened Immortal lists are doing right now they're self experimenting with desitin AB without any problems so we've finally hopefully identified a pharmacist and by the way we're calling all around the country to to encourage the pharmacist to compound this because it's different than this price'll drug the desitin app for age reversal is individually dosed based on your body weight so it should be compounded you shouldn't try to use a different dose that's abate available through pharmacies and a study that we reported on last month this is the company backed by Jeff Bezos and other very wealthy people they are identifying other sin oolitic compounds that are demonstrating safety and a degree of efficacy and very initial studies I predict the next three or four years there'll be many many settlement of compounds out there but in the meantime you need to take advantage of what's available right now now this is a brand that's at anab that has been imported from other countries by a number of people and they've used it no side effects whatsoever but we wanted to independently assay it to assure that it had the proper amount of dassit in a Bennett to induce a meaningful benefit and we put it through an extensive test we tested it against price'll we tested it against Sigma derived desitin AB where it's a very high quality research grade and the drug came out to be perfect this low cost drug available from other countries identical to the Spry sole that in this country cost an absolute fortune now one of our members John John you can stand up if you'd like he has made some connections with some people in with overseas in Canada other kind of pharmacies and if you have a prescription he can help you obtain it and and what we've encouraged some people to do is maybe work with John all get together and pitch in and buy a couple bottles of dassit in AB because you don't need that many tablets each person may only need four to six tablets and this bottle contains sixty of them I think so you could potentially have nine or ten people chip in and your cost is very very low and so John's offered to assist people he's going to do it himself to basically make a group purchase of only a couple bottles and in that way you can obtain the benefits of cinah lytx at a low price courses and of course available anywhere very low cost dietary supplement so the idea of being able to take advantage of cinematic therapy it's now becoming real now the people who want to live forever like me they're working with others to put together big money to do large human studies we can't wait for it to happen this was announced earlier this month Peter Diamandis he's an incredibly brilliant researcher businessman he gives talks on immortality all the time goes around the world telling people you don't have to die technology is advancing fast enough so if you take care of yourself now you may live forever and he's putting together a 100 million dollar longevity vision fund to support research and these are the people he's partnered with the younger guys Sergey Jung the younger one he's gonna do most of the work Jim Mellon is a billionaire he travels the world encouraging people to invest money in age reversal research he convinces a lot of people that this is probably the most significant way of growing your money because I think when age reversal research develops into clinical therapies it will be bigger than Apple here people will need more of it it'll be universal people will not want to let aging take its course some of you may know Alex saw Veronica this is a very interesting individual who's pioneered a form of deep learning artificial intelligence where he's able to identify probable compounds and combination of compounds that can slow and reverse aging you get a nice write-up in Forbes magazine this month Alex by the way does not have a home or an apartment he never stops traveling to scientific conferences to meet with groups of scientists to put together research projects aimed at defeating the aging process we've had a long term relationship with Alex he's somebody when you hear him talk and you see what he's doing you realize there are some very smart people and he's sacrificing his own health for this his biological age is four to five years older than his chronological age is because of the stress he puts on himself to accelerate human age reversal research and this is the diagram that was in Forbes magazine and what it shows is what happens to people when they're born and they mature and then around the age of 35 to 40 they start to decline now if you do nothing about it you decline rather quickly you fall ill you might be in a nursing home for a couple years and then a cemetery but if you engage if you engage in some preventative type measures like Ryan Delaney talked about like some of the interventions we spoken about at this church for many many years well you can delay that you can live longer by intervening in aging today and then the ultimate objective is to not let the downhill curve occur at all in other words diagnose and repair damage that occurs during aging so that you never have to think about nursing homes and cemeteries it'll be a fantastic future so Forbes they wrote some very nice verbiage about age reversal research being the ultimate form of altruism the ultimate the ultimate charitable act because it benefits everybody including yourself if we don't die of something aging will kill us and virtually everything we die of today is a degenerative disorder related to normal biological aging and this is the last slide deck I'm going to really show you look at the headline of this and it pretty much acknowledges that science will emerge to enable people to live maybe forever and then they have that headline that immortality is a fate worse than death now you can see what they write in there they're talking about the scientist the billionaire is putting money into this and getting real-world results they're talking about that and I kept wondering looking reading this whole article I said well where is the downside to this III couldn't figure out what they were getting at because they're talking about the most brilliant entrepreneurs in the world putting big money into research designed to find a cure for biological aging so I'm reading all this good stuff and I'm saying why is that headline there why are they calling immortality a fate worse than death and again the data they kept presenting and writing about this article indicates this is going to happen I mean these people made the impossible occur already and they're looking at aging is just another technological challenge so this I believe is the only verbiage in this entire long article that this talks about why this is so terrible well number one it's going to be too expensive everything is too expensive when it first comes out we know that remember buying cell phones for $2,000 that barely had a connection anywhere and didn't work too well $2,000 is what they cost back in 1988 we now buy smart phones for six $700 that do so much more as technology advances prices come down as this will not only be for billionaires though in the beginning to probably be some interventions to do billionaires can afford that others can't and then they bring up the ridiculous notion that somehow there's going to be too many people on this planet now we've had so many credential speakers in this church totally invalidate that assumption with one slide after another I'm really just gonna show you one and that is Japan Germany France and even China they are losing their population people are dying more frequently than are being born and that population shrinkage is going to hinder those countries and that would be happening in the United States also if it wasn't for all the immigration we are also not replacing ourselves as Americans as fast as we need to but we don't have to worry about it we've got plenty of new people coming in but people don't move to China or Russia like they do to this country Russia is another country by the way where their population is shrinking to the point in the next 50 to 100 years there may not be many Russians around that's how fast it's happening so when some persons writing an article and get this preposterous assumption that we're going to run out of room on this planet the fact of the matter is we need more people we need more mature people who've got the experience to make real-world differences occur in this world and again this is the demographic forecast for Japan it is pathetic they are going to be stuck with a lot of old people Japan by the way is the country with the longest living people in the world so they're gonna have lots of old people and not enough young ones to support them they've got a real problem they would like to make those old people young and productive again that would resolve their problems so again the breakthrough of the month so to speak is transplanting young bone marrow into old mice and theoretically some of us could do that now you can remove bone marrow from a young healthy person it does grow back and a young healthy person put it into your own body and that young bone marrow would churn out a lot of healthy cells theoretically we don't know the safety of it yet I don't advise anyone doing it yet but at least it provides evidence that aging is very much involved with bone marrow degeneration and there are other ways to derive the benefits of young bone marrow that we are investigating and this was all predicted by many many people and it's evidenced by what you're looking at right now most of us are old enough to remember a lot of people who drop dead of a heart attack and yet starting in 1980 technologies and healthier living patterns resulted in a 50% overall decrease in deaths from any form of heart disease a 50% reduction over this period of time in which people started thinking if I do something to prevent a heart attack maybe I won't have one guess what it worked so and Franklin predicted all this was gonna happen he predicted that technology would advance to the point where what was killing people in his era and people in his area lived to an average age of 35 years now that is a little bit misleading because the infant mortality rate very high and the maternal a mortality rate delivering a baby a lot of women died so it didn't mean that most people died at 35 but what it meant is people weren't living very long and by 1900 that average only went up to about 47 years average lifespan so Ben Franklin is predicting way back and late 1700s that technology is going to enable people to live a lot longer diseases be cured well most of the diseases that Franklin knew about they've been cured already antibiotics get rid of all those bacterial infections tuberculosis atheria pneumonia diarrhea even caused by various microbes have been eliminated for the most part and antiviral therapies have moved ahead with vaccines in which people don't die a smallpox anymore so what he predicted is that science will emerge to eventually cure all of the diseases of aging including the aging process himself and we're seeing that happen right before our eyes and I just want to induce one more individual a dr. rich Gaines if you'd like to stand up dr. Gaines is a medical doctor practice in Boca Raton and he had a grand opening for his clinic about three weeks ago and I attended it to show support I didn't expect there would be a lot of people there because we didn't announce it through our church or through the many other age reversal networks so I just didn't know how many people were going to be there but I want to be there to show support he's going to enable people to gain access to affordable and AD infusions Senna lytx certainly metformin which is a basic we should all be involved in and then more advanced biologics that we're exploring and the work that Tonya did and with dr. Gaines network of people that he's been involved in we had about 200 people show up for this grand opening including the local CBS affiliate for Palm Beach County and they interviewed me and a number of other people and I made it clear this may be the first age reversal medical clinic in history where they're going to focus on ways to reverse aging utilizing protocols you've learned in this church and what I'm hoping is in addition to what dr. Gaines is doing in Boca that more and more doctors add age reversal to the services that they offer so you can have doctors convenient to you in your neighborhood but dr. Gaines will be around if you want to talk to him you've got Alan Zimmer right here at the pharmacist who's going to compound some of these drugs at very low prices and John he's going to help you get some of these medications offshore in case you don't want to pay the prices in this country or just can find it easier to order from a canadian pharmacy with a prescription then what you would locally so we've we're making progress here at this church we're talking about technologies and people on their own are coming forward saying I can help I can do something so we're seeing the progress occur so that is the end of my talk I'll be happy to answer any questions [Applause] you public we have time for a few questions for bill questions for bill Jordan by the way we are going to have Bill's PowerPoint on our website as well so you'll be able to access that in a few days John yeah if you could make a brief comment on a study that I just mentioned to you earlier about faceting or Fitton I'm not sure how I put that strawberry flavonoid it looks according to the data that I reviewed have a senescent clearance capability that was comparable to the Senate to have in quercetin which is pretty bold statement and it was in rats not humans yet but it what it whet my appetite suffice to say let me explain what we're researching right now there is a strawberry flavonoid called fistin or Phi Citan however you want to describe the word phonetically but it seems to have potent syn oolitic properties the dilemma at the moment is like a lot of polyphenols and plants it does not absorb particularly well so I'm funding research right now to find a way to make the FISA 10 highly absorbable so it can get into the bloodstream and induce the syn oolitic effect so we know it works it's been working in animal models where they make sure the animals just get enough in their bloodstream we need to find a way to make it absorbable in people so they can take it once a week however often the protocol calls for so I would think in the next 9 to 12 months there'll be by certain available it is expensive by the way so if you're going to take a lot of it and it doesn't absorb well it's almost cheaper to use to asset in it so that that's one factor but absorbability is the key so research is ongoing right now I'm paying for it to see if we can get isit unavailable which you could buy without a prescription and get these syn oolitic benefits as often as you want and as Brian mentioned with new testing being available to identify how many senescence cells you're removing you may be able to individually dose it maybe take it once a month once every three months and that could mean the cost really gets low yeah human research that's all I find nowadays is human studies rushing from John good evening what website specifically do you recommend for offshore purchasing well there's a group called international anti-aging systems IAS they're a little bit challenged right now because the government doesn't like what they do so the government has caused the banks to make it difficult for them to accept checks and credit cards but nonetheless they're in business they make number of compounds like rapamycin metformin available they're gonna make some tacit in have available at an affordable price and the biggest challenge is just being able to get through to them the government does everything they can to sabotage them because the big pharma companies don't like low-cost competition some people are asking for information